Maciej Spiegel, MPharm PhD - Computational Chemist

About Me

Maciej Spiegel

MPharm PhD computational chemist specializing in drug design, antioxidant mechanisms, and photodynamic therapy. Based at Wroclaw Medical University, I combine quantum chemistry with molecular modeling to develop next-generation therapeutic agents.

35+ Publications 800+ Citations h-index: 14
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Research Interests

🧬

Senotherapeutics

Targeting senescent cells through computational drug design to prevent age-related diseases and extend healthspan.

🎗️

Anticancer Agents

Designing novel compounds including photosensitizers, platinum complexes, and BODIPY agents with selective toxicity.

🌿

Dietary Antioxidants

Elucidating mechanisms of polyphenol activity against oxidative stress using quantum chemical methods.

Computational Workshop

My research employs state-of-the-art computational chemistry software and methodologies and programming:

  • Quantum Chemistry: Gaussian, ORCA, Q-Chem
  • Molecular Dynamics: GROMACS, AMBER
  • Docking & Virtual Screening: AutoDock Vina
  • Python Programming: scikit-learn, matplotlib, numpy, scipy

Collaboration Opportunities

I am actively seeking collaborations in:

  • Computational drug design and optimization
  • Synthesis of the new compounds
  • Elucidation of the mechanisms
  • Senotherapeutic agent discovery
  • Method development and benchmarking studies

Interested? Get in touch!

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Address

Department of Organic Chemistry and Pharmaceutical Technology
Faculty of Pharmacy
Wroclaw Medical University
Borowska 211A
Wroclaw, Poland

"I commend widely his professional and personal behavior."

— Prof. Nino Russo

"Maciej has, despite a pharmaceutical study curriculum, an excellent background in computational chemistry."

— Prof. Carlo Adamo

"He is very intelligent, hard-working, independent and rigorous in his attitude toward science."